Anion exchange resins in phosphate form as versatile carriers for the reactions catalyzed by nucleoside phosphorylases

• Julia N. Artsemyeva,
• Ekaterina A. Remeeva,
• Tatiana N. Buravskaya,
• Irina D. Konstantinova,
• Roman S. Esipov,
• Anatoly I. Miroshnikov,
• Natalia M. Litvinko and
• Igor A. Mikhailopulo

Beilstein J. Org. Chem. 2020, 16, 2607–2622, doi:10.3762/bjoc.16.212

• Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, 117997 GSP-7, Moscow B-437, Russian Federation 10.3762/bjoc.16.212 Abstract In the present work, we suggested anion exchange resins in the phosphate form as a source of phosphate, one of the

• were tested in the synthesis of nelarabine, kinetin riboside, and cladribine with good to excellent yields (52–93%). Keywords: anion exchange resins; N6-benzyladenosine; cladribine; enzymatic glycosylation; kinetin riboside; nelarabine; α-ᴅ-pentofuranose-1-phosphates; phosphorolysis of nucleosides

• MeCN; 99.0% purity according to HPLC; for NMR data, see Supporting Information File 1, SI-1, SI-2 and SI-4). The capacity of the anion exchange resins to bind PF-1Pi As noted above, when studying Ara-U phosphorolysis catalyzed by E. coli UP in the presence of Dowex-nPi, we found that (1) about 10% of

Highly selective generation of vanillin by anodic degradation of lignin: a combined approach of electrochemistry and product isolation by adsorption

• Dominik Schmitt,
• Carolin Regenbrecht,
• Marius Hartmer,
• Florian Stecker and
• Siegfried R. Waldvogel

Beilstein J. Org. Chem. 2015, 11, 473–480, doi:10.3762/bjoc.11.53

• formation of vanillin (1) and a novel as well as viable work-up concept exploiting strongly basic anion exchange resins. As renewable feedstock we employed alkaline lignin solutions. Alloys of cobalt and nickel as anodic material are suitable forming in situ electrochemically active MO(OH) coatings. Despite

• related phenols from the alkaline electrolyte. An easy to perform enrichment of the desired product by adsorption at strongly basic anion exchange resins was established. The larger lignin particles were not bound to the gel-type resins because the size exclusion effect does not affect them. Only small

• solutions after electrochemical treatment at Ni foam electrodes. Different amounts of resin were applied in a batch process. Desorption was performed treating the loaded resins with an acidic solution (EtOAc/AcOH, 8:2) in a batch process. Adsorption of vanillin (1) on anion exchange resins and size